Chronic fatigue syndrome, or CFS, is a mysterious disorder we still don’t know much about. Though there are suggestions that CFS can be triggered by hormonal imbalances, stress, a weakened immune system, or some viral infections, its exact cause remains unknown.
As the FDA has yet to approve an official treatment for CFS, though lifestyle changes are generally recommended, especially when it comes to caffeine intake. On the rare occasion, medical professionals may even prescribe antidepressant therapy.
However, there may be a possible treatment through the use of hemp flower. This bud comes off of hemp plants, and while they may look a lot like cannabis trichomes, they won’t get you high, since they don’t contain nearly enough of the psychoactive component, THC to create that effect. What hemp flower does contain, though, is an abundance of therapeutic terpenes and cannabinoids, one of which being the famous CBD.
While there is no research yet on how it affects the disease itself, hemp flower may be a viable treatment on some of the typical symptoms of CFS, including chronic insomnia, muscle pains and difficulty concentrating.
In this article, we’ll review some of our favorite strains for combatting CFS. At the end of the list, we’ll discuss how these hemp flower strains for chronic fatigue can help with this condition’s characteristic symptoms of insomnia and chronic pain.

1: Bubba Kush from Dr. Ganja
Bubba Kush is a strain known for its relaxing, sleep promoting properties, which uses its equal balance of humulene and limonene, which are touted for their soothing benefits, along with anti-inflammatory caryophyllene, so that they’re sure to give off both a mental and bodily relaxation.
With that in mind, it will probably come as no surprise that this strain is indica-dominant, so that the use of it is going to pull you right into that good night’s sleep you’ve been trying to make up for.
On Dr. Ganja’s site, Bubba Kush appears to be one of their most widely-praised strains sold. Not to mention that this product is unusually high in CBD for its strain, and its cannabinoid levels come in at around 18.25%.
Bubba Kush features vibrant emerald hues, and earthy smell and springy, fluffy buds. This strain is especially enjoyed for its flavor; while the folks at Dr. Ganja describe this strain as piney and earthy, it is often described by enthusiasts as sweet, while creating a smooth burn when smoked.
It’s also regularly remarked on for its sleep promoting abilities, which is no doubt thanks to not only the listed muscle-relaxing terpenes, but also myrcene, which can often work well with inducing sleep. Additionally, it also contains .06% CBG, which helps to relieve inflammation by performing neuroprotective functions throughout the nervous system.
As is usually the case with Dr. Ganja’s products, you’re going to get a lot of value from its prices. Bubba Kush comes at $10 per gram, but you can buy 3.5{61a9c4ebdbb811fd2382c102d8e69c6b7b78aa8e69b88e3f73a4ac056945b5db} for $25. When you combine the price with all of the highlights of the strain’s profile, you know you’re getting an amazing deal.
- CBD: 16.48%
- D9-THC: .03%
- CBG- .06%
- Beta-myrcene- .078%
- Alpha-Humulene .104%
- Beta-Caryophyllene .50%
- Limonene .040%
WHERE TO BUY?
DRGANJA.COM

2: Lifter from Tweedle Farms
This Oregon-grown strain is reminiscent of astringent berries and tropical fruit. Featuring dense, resinous buds, this strain is especially distinct for its neat structure and shape.
D9-THC is the THC we refer to as the psychoactive component, and while this high-inducing cannabinoid is only .09{61a9c4ebdbb811fd2382c102d8e69c6b7b78aa8e69b88e3f73a4ac056945b5db}, the total THC is .75{61a9c4ebdbb811fd2382c102d8e69c6b7b78aa8e69b88e3f73a4ac056945b5db}, which helps to strengthen cannabinoids for promoting the entourage effect.
Unlike Bubba Kush, this very slightly sativa-dominant strain shouldn’t make you feel drowsy, it’s not as strongly recommended for sleep.
That being said, it doesn’t necessarily work like your morning cup o’joe, either, as it won’t give the user the effect of jitters or shakes.
Not only does this function make Lifter especially valuable to those with CFS who need to curb their symptoms of chronic drowsiness and fatigue, but it’s also useful for those who need extra stimulation without working up their nerves.
Instead, Lifter appears to work entirely true to its name: fans of it describe the effect as “elevating” or “meditative,” as it provides an almost hypnotic sense of focus, but your body will stay relaxed, especially with the help of alpha-pinene, which, while it will not necessarily make you drowsy, it can promote the efficiency of sleep when in non-REM mode, which may improve wakefulness with long-term use.
This strain goes at $25 per ounce, or $40 for 2 ounces, $70 for 4 and $200 for 16 and so on, ensuring that you get the best bang for your buck.
- CBD: 19.10%
- D9-THC: .09%
- Myrcene: .73%
- Beta-Caryophyllene .44%
- Alpha-Pinene .1%
WHERE TO BUY?
TWEEDLEFARMS.COM

3: Paradise OG from CBD Hemp Direct
This strain is remarkably rich in CBD and extremely low in THC. Plus it’s rich in relaxing, therapeutic terpenes, especially caryophyllene and myrcene. Paradise OG is grown organically on Paradise road near the Las Vegas strip.
Paradise OG is especially concentrated in relaxation-inducing myrcene, which acts as a mild sedative. Moreover, it contains beta-caryophyllene, which, in addition to working as an antibacterial, anti-inflammatory aid, it can also work especially efficiently because of the way it binds to the ECS. Because of this, beta-caryophyllene behaves in a way that’s similar to cannabinoids.
Paradise OG is also rich in humulene, which is extremely popular for providing inflammation relief. In this study, it was shown that humulene’s anti-inflammatory, preventive properties can help with autoimmune symptoms.
Besides chronic pain and drowsiness, Paradise OG is also ideal for depression, stress and muscle spasms, and as a sativa-dominant strain, it will keep you awake and alert without leaving you wired, and features a dank, musky aroma.
Hemp flower is also abundant in guaiol, which is a rather underrated terpene in the hemp flower world. While most terpenes are oil-based, guaiol is unique in that it’s liquid-based, and it’s characterized as an evergreen aroma. Guaiol works as an anti-inflammatory, antibacterial agent rich in antioxidants, which can help support a healthy immune system.
Not only does this strain provide pain and inflammation relief, it can also help strengthen the body’s immune response to foreign pathogens.
- CBD: 18.7%
- D9-THC: less than .001% (undetectable)
- Myrcene: .76%
- Beta-Caryophyllene: .22%
- Humulene: .1%
WHERE TO BUY?
CBDHEMP.DIRECT

4: Kush-E from Mr. Hemp Flower
This aromatic strand crushes anxiety with its especially high levels of beta-myrcene, which acts as a mild tranquilizer, with even levels of alpha-pinene and limonene working together to improve your sleep quality.
This strain is especially useful for those with symptoms of anxiety because it contains a balanced duo of linalool and limonene.
Linalool is the terpene that gives lavender its reputation as a soothing, medicinal herb, not to mention it works strongly as an anti-inflammatory agent. Meanwhile, limonene is a powerful antioxidant that can stimulate the immune system, reduce anxiety and provide gastric relief.
Kush-e makes springy, green, round little buds that crack open to reveal astringent grapes and exotic berries, revealing the abundance of alpha-pinene, which can make rest more efficient.
It’s also high in myrcene, and while this terpene tends to be abundant in a lot of hemp flower strains, it’s still beneficial to see, especially when you want to relax your body and protect it from future infection
Plus, the CBD levels in this strain are modest, but shouldn’t worry those who find that CBD can make them sleepy.
This strain provides an especially enjoyable flavor the entire time you use it. Kush-e can help those who wish to seek relief from chronic pain, especially those sustaining a past injury.
- CBD: 15.8%
- D9-THC: less than .03%
- Alpha-Pinene- .05%
- Beta-Myrcene- .26%
- Limonene- .05%
WHERE TO BUY?
MRHEMPFLOWER.COM

5: Merlot from Industrial Hemp Farms
This premium indoor strain is produced from the cross-breeding of Cherry Wine and Berry Blossom, and makes buds on the longer side, which feature the dank, rich aroma that reveals a strong terpene profile.
Merlot is a hybrid, so it should not make a big impact upon your drowsiness or wakefulness while still helping to relax your body. However, some individuals have reported feeling extra ready for their bedtimes after taking it, so it may be recommended to try a small amount first.
These relaxation properties are thanks to the hemp flower strain’s dominance of myrcene, beta-caryophyllene, and alpha-bisabolol. When these relaxing terpenes are combined, they bring out each other’s therapeutic benefits for promoting rest.
Myrcene is anti-inflammatory and works to relax the muscles, while beta-caryophyllene can prevent the onslaught of bacteria while soothing anxiety, pain and inflammation.
Meanwhile, beta caryophyllene helps reduce anxiety, pain and inflammation, while alpha-bisabolol works as a powerful anti-inflammatory agent.
The buds produced from Merlot are woven throughout with peach-colored pistils and a golden tinge.
Upon first sniff, the individual will probably notice the dank, skunky aroma of the bud, which exudes the rich terpene profiles within. When these buds are broken down, they release notes of ripe tropical fruit and sweet gas, and produces a flavor that enthusiasts often compare to Cherry Wine.
- CBD: 15.66%
- D9-THC: less than .02%
- Myrcene: .32%
- Beta-Caryophyllene: .14%
- Alpha-Bisabolol: .08%
WHERE TO BUY?
INDUSTRIALHEMPFARMS.COM
How Hemp Flower Helps Chronic Fatigue
How Cannabinoids Work
Cannabinoids are unique because of the way they interact with our bodies: when CBD or hemp products are administered, they are introduced to the endocannabinoid system, or ECS. The ECS is a series of receptors responsible for pain management, sleep regulation, and mood levels.
CBD, though, is also a cannabinoid, so it’s naturally drawn to these receptors and attaches to them. Through this interaction, CBD helps promote pain management functions by dulling the pain receptors, improving the reception of serotonin, and reducing inflammation.
Cannabinoids also play a big role in regulating sleep and relaxation. For instance, this study showed that CBD can help with anxiety-induced sleep disorders. CBD can assist in sleep (among other functions like mood and appetite) by interacting with CB1 and CB2 receptors. Because of this unique interaction, CBD may even help relax the nervous system and optimize melatonin production.
How Terpenes Work
Terpenes, on the other hand, are known to help treat inflammation and stress in their own unique way.
Terpenes are organic compounds found in a broad range of plants; not only hemp and cannabis, but also in oregano, hops, lavender and sage, and their function is believed to protect plants from foragers in the wild. Interestingly, they also give plants their distinct aromas, and more than that, they’ve been found to be highly therapeutic, especially for relieving stress.
While they are valuable in their own right, terpenes are especially crucial for the way in which they interact with cannabinoids: not only do their combined properties enhance each other, but also because they create a synergistic connection that can amplify the overall benefits, known as the entourage effect.
Through this interaction, terpenes have been shown to assist with a number of ailments varying from anxiety and insomnia to joint and muscle pain.
When it comes to treating pain, the best strains will be rich in the following terpenes:
- Beta-Myrcene
Beta-myrcene acts as an anti-inflammatory agent and relaxes the muscles, and can cause a mild sedative effect, making it particularly useful for sleep-inducing strains like Kush-E.
Aroma: mango, fruity, earthy, grape
Found in: hops, mango, lemongrass, thyme
- Limonene
Limonene is a powerful antioxidant that can reduce stress, improve mood, and alleviate inflammation. This sunny terpene can also stimulate your immune system, better protecting yourself from getting sick.
Aroma: citrus
Found in: fruit rinds, peppermint, rosemary
Meanwhile, the following terpenes are especially beneficial for insomnia:
- Alpha-Pinene
Alpha-pinene is an anti-inflammatory terpene not only helps manage pain, but also helps with increasing non-REM sleep.
Aroma: piney, herbal
Found in: pine, rosemary
- Beta-Caryophyllene
Beta-caryophyllene acts the most like a cannabinoid in that it actually binds to the ECS. Beta-caryophyllene can soothe anxiety, pain and inflammation, and works as an antibacterial agent.
Aroma: wood, clove, spice
Found in: basil, pepper, hops, cloves
- Linalool
Linalool is a relaxing terpene most commonly used for anxiety and pain, as its soothing effects relax the muscles and slows the body for rest, as well as regulate breathing and reduce inflammation.
Aroma: floral, sweet
Found in: lavender
Conclusion/Takeaway
While there is still no definitive on the treatment of chronic fatigue syndrome, hemp flower may help with some of the symptoms that come with it, like insomnia, inflammation and chronic pain. When selecting a strain, always choose from a reputable brand, and stick with terpenes known for helping sleep and pain management.
FAQs
Unfortunately, there is still no known cure for chronic fatigue, and hemp flower is no exception. However, hemp flower may help to curb the symptoms that come with chronic fatigue.
Depending on the strain’s profile, hemp flower can treat symptoms surrounding chronic fatigue by targeting insomnia and chronic pain.
Hemp flower is completely legal, and can be bought and sold in any state in the United States.